Myogenic Vasoconstriction Requires Canonical G_q/11 Signaling of the Angiotensin II Type 1 Receptor.

ABSTRACT: Background Blood pressure and tissue perfusion are controlled in part by the level of intrinsic (myogenic) arterial tone. However, many of the molecular determinants of this response are unknown. We previously found that mice with targeted disruption of the gene encoding the angiotensin II type 1a receptor (AT1AR) (Agtr1a), the major murine angiotensin II type 1 receptor (AT1R) isoform, showed reduced myogenic tone; however, uncontrolled genetic events (in this case, gene ablation) can lead to phenotypes that are difficult or impossible to interpret. Methods and Results We tested the mechanosensitive function of AT1R using tamoxifen-inducible smooth muscle-specific AT1aR knockout (smooth muscle-Agtr1a^-/-) mice and studied downstream signaling cascades mediated by G

SUBMITTER: Cui Y 

PROVIDER: S-EPMC9245832 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature