Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state.
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ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC9246109 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Metabolic and epigenetic dysfunctions underlie the arrest of in vitro fertilized human embryos in a senescent-like state.
Yang Yang Y Shi Liyang L Fu Xiuling X Ma Gang G Yang Zhongzhou Z Li Yuhao Y Zhou Yibin Y Yuan Lihua L Xia Ye Y Zhong Xiufang X Yin Ping P Sun Li L Zhang Wuwen W Babarinde Isaac A IA Wang Yongjun Y Zhao Xiaoyang X Hutchins Andrew P AP Tong Guoqing G
PLoS biology 20220630 6
Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3- to 8-cell stage, posing a significant clinical problem. The mechanisms behind this arrest are unclear. Here, we show that the arrested embryos enter a senescent-like state, marked by cell cycle arrest, the down-regulation of ribosomes and histones and down-regulation of MYC and p53 activity. The arrested embryos can be divided into 3 types. Type I embryos fail to complete the maternal-zygot ...[more]
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