Interferon gamma release assays for diagnosis of osteoarticular tuberculosis: A systematic review and meta-analysis.

ABSTRACT:

Background

Although the Interferon Gamma Release Assays (IGRA) is often used to identify latent tuberculosis, it also plays a crucial role in diagnosing active extrapulmonary tuberculosis. Some studies have assessed the use of IGRA as a biomarker for osteoarticular tuberculosis (OATB), which is elevated following TB infection. Still, conclusive results about its effectiveness have not been reported.

Method

We searched PubMed, Embase, and Cochran databases. We obtained literature related to the diagnosis of OATB by IGRA, and the retrieval period was from the establishment of the database to June 2021. The bivariate random effect model was used to summarize the sensitivity, specificity, and accuracy of other indicators in diagnosing OATB by IGRA, and the forest plot and receiv

SUBMITTER: Ren C 

PROVIDER: S-EPMC9246147 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature