The HDAC9-associated risk locus promotes coronary artery disease by governing TWIST1.

ABSTRACT: Genome wide association studies (GWAS) have identified thousands of single nucleotide polymorphisms (SNPs) associated with the risk of common disorders. However, since the large majority of these risk SNPs reside outside gene-coding regions, GWAS generally provide no information about causal mechanisms regarding the specific gene(s) that are affected or the tissue(s) in which these candidate gene(s) exert their effect. The 'gold standard' method for understanding causal genes and their mechanisms of action are laborious basic science studies often involving sophisticated knockin or knockout mouse lines, however, these types of studies are impractical as a high-throughput means to understand the many risk variants that cause complex diseases like coronary artery disease (CAD). As a solution

SUBMITTER: Ma L 

PROVIDER: S-EPMC9246173 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature