Comprehensive proteomic quantification of bladder stone progression in a cystinuric mouse model using data-independent acquisitions.

ABSTRACT: Cystinuria is one of various disorders that cause biomineralization in the urinary system, including bladder stone formation in humans. It is most prevalent in children and adolescents and more aggressive in males. There is no cure, and only limited disease management techniques help to solubilize the stones. Recurrence, even after treatment, occurs frequently. Other than a buildup of cystine, little is known about factors involved in the formation, expansion, and recurrence of these stones. This study sought to define the growth of bladder stones, guided by micro-computed tomography imaging, and to profile dynamic stone proteome changes in a cystinuria mouse model. After bladder stones developed in vivo, they were harvested and separated into four developmental stages (sand, small, medium

SUBMITTER: Rose J 

PROVIDER: S-EPMC9246204 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature