A computational model of rabbit geometry and ECG: Optimizing ventricular activation sequence and APD distribution.

ABSTRACT: Computational modeling of electrophysiological properties of the rabbit heart is a commonly used way to enhance and/or complement findings from classic lab work on single cell or tissue levels. Yet, thus far, there was no possibility to extend the scope to include the resulting body surface potentials as a way of validation or to investigate the effect of certain pathologies. Based on CT imaging, we developed the first openly available computational geometrical model not only of the whole heart but also the complete torso of the rabbit. Additionally, we fabricated a 32-lead ECG-vest to record body surface potential signals of the aforementioned rabbit. Based on the developed geometrical model and the measured signals, we then optimized the activation sequence of the ventricles, recreating

SUBMITTER: Moss R 

PROVIDER: S-EPMC9246225 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature