Risk and Protective Factors for Sudden Cardiac Death: An Umbrella Review of Meta-Analyses.

ABSTRACT:

Background

Sudden cardiac death (SCD) is a global public health issue, accounting for 10-20% of deaths in industrialized countries. Identification of modifiable risk factors may reduce SCD incidence.

Methods

This umbrella review systematically evaluates published meta-analyses of observational and randomized controlled trials (RCT) for the association of modifiable risk and protective factors of SCD.

Results

Fifty-five meta-analyses were included in the final analysis, of which 31 analyzed observational studies and 24 analyzed RCTs. Five associations of meta-analyses of observational studies presented convincing evidence, including three risk factors [diabetes mellitus (DM), smoking, and early repolarization pattern (ERP)] and two protective factors [implanted cardiac

SUBMITTER: Tsartsalis D 

PROVIDER: S-EPMC9246322 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature