Extracts of Gluconacetobacter hansenii GK-1 induce Foxp3⁺T cells in food-allergic mice by an IL-4-dependent or IL-4-independent mechanism.

ABSTRACT: The biological activities of acetic acid bacteria (AAB) as Gram-negative bacteria have attracted our interests, especially in their inhibitory effects on allergic responses. To clarify the underlying mechanism that improves allergic symptoms by ingestion of the AAB Gluconacetobacter hansenii, we examined whether different extracts of heat-killed G. hansenii GK-1 could reduce the interleukin (IL)-4 production of immune cells from food-allergic model of OVA23-3, transgenic mice with ovalbumin (OVA)-specific T-cell-receptor genes. A hot-water extract fraction (FII) of G. hansenii GK-1 significantly decreased the in vitro IL-4 production of spleen cells of OVA23-3 mice compared with those stimulated with OVA alone. The IL-4 inhibitory effect was also observed for FI

SUBMITTER: Nakajima-Adachi H 

PROVIDER: S-EPMC9246422 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature