Spatially resolved neural slowing predicts impairment and amyloid burden in Alzheimer's disease.

ABSTRACT: An extensive electrophysiological literature has proposed a pathological 'slowing' of neuronal activity in patients on the Alzheimer's disease spectrum. Supported by numerous studies reporting increases in low-frequency and decreases in high-frequency neural oscillations, this pattern has been suggested as a stable biomarker with potential clinical utility. However, no spatially resolved metric of such slowing exists, stymieing efforts to understand its relation to proteinopathy and clinical outcomes. Further, the assumption that this slowing is occurring in spatially overlapping populations of neurons has not been empirically validated. In the current study, we collected cross-sectional resting state measures of neuronal activity using magnetoencephalography from 38 biomarker-confirmed pa

SUBMITTER: Wiesman AI 

PROVIDER: S-EPMC9246709 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature