Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.

ABSTRACT: The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion syndrome, post-impact catastrophic death, and delayed neurodegeneration remain poorly understood. This limited pathophysiological understanding has hindered the development of diagnostic and prognostic biomarkers and has prevented the advancement of treatments for the sequelae of mild traumatic brain injury. We aimed to characterize the early electrophysiological and neurovascular alterations following repetitive mild traumatic brain injury and sought to identify new targets for the diagnosis and treatment of individuals at risk of severe post-impact complications. We combined behavioural, electrophysiological, molecular, and neuroimaging techniques in a rodent model of repetitive mild tra

SUBMITTER: Parker E 

PROVIDER: S-EPMC9246711 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature