Combining Mechanisms of Growth Arrest in Solid Tumours: A Mathematical Investigation.

ABSTRACT: The processes underpinning solid tumour growth involve the interactions between various healthy and tumour tissue components and the vasculature, and can be affected in different ways by cancer treatment. In particular, the growth-limiting mechanisms at play may influence tumour responses to treatment. In this paper, we propose a simple ordinary differential equation model of solid tumour growth to investigate how tumour-specific mechanisms of growth arrest may affect tumour response to different combination cancer therapies. We consider the interactions of tumour cells with the physical space in which they proliferate and a nutrient supplied by the tumour vasculature, with the aim of representing two distinct growth arrest mechanisms. More specifically, we wish to consider growth arrest d

SUBMITTER: Colson C 

PROVIDER: S-EPMC9246818 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature