Reduced cortical volume of the default mode network in adolescents with generalized anxiety disorder.

ABSTRACT:

Background

Widespread structural alterations have been shown to be implicated in individuals with generalized anxiety disorder (GAD). However, there have been inconsistent findings in cortical volume (CV) differences. Most structural neuroimaging studies looking at GAD used region-based approach with relatively small sample sizes, let alone be specific to adolescents with GAD. We believe this is the first study to look at CV measures using a network-based approach in a larger sample of adolescents with GAD. The goal of the current study was to focus on three different brain networks (i.e., Limbic, Frontoparietal, and Default Mode Network [DMN]) in adolescents with GAD.

Method

The study involved 81 adolescents with GAD and 112 typically developing (TD) comparison individuals

SUBMITTER: Bashford-Largo J 

PROVIDER: S-EPMC9246827 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature