Whole-exome DNA sequencing in childhood anxiety disorders identifies rare de novo damaging coding variants.

ABSTRACT:

Background

Genetic factors contribute to the development of anxiety disorders, yet few risk genes have been previously identified. One genomic approach that has achieved success in identifying risk genes in related childhood neuropsychiatric conditions is investigations of de novo variants, which has yet to be leveraged in childhood anxiety disorders.

Methods

We performed whole-exome DNA sequencing in 76 parent-child trios (68 trios after quality control) recruited from a childhood anxiety disorder clinic and compared rates of rare and ultra-rare de novo variants with 790 previously sequenced control trios (783 trios after quality control). We then explored overlap with risk genes for other neuropsychiatric conditions and enrichment in biologic pathways.

Results

Rare

SUBMITTER: Olfson E 

PROVIDER: S-EPMC9246845 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature