Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population.

ABSTRACT:

Background

A strong predictor for the development of alcohol use disorder (AUD) is altered sensitivity to the intoxicating effects of alcohol. Individual differences in the initial sensitivity to alcohol are controlled in part by genetic factors. Mice offer a powerful tool to elucidate the genetic basis of behavioral and physiological traits relevant to AUD, but conventional experimental crosses have only been able to identify large chromosomal regions rather than specific genes. Genetically diverse, highly recombinant mouse populations make it possible to observe a wider range of phenotypic variation, offer greater mapping precision, and thus increase the potential for efficient gene identification.

Methods

We have taken advantage of the Diversity Outbred (DO) mouse populat

SUBMITTER: Parker CC 

PROVIDER: S-EPMC9246903 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature