Inflammatory and Immune Protein Pathways Possible Mechanisms for Pain Following Walking in Knee Osteoarthritis.

ABSTRACT:

Background

Knee osteoarthritis affects nearly 30% of adults aged 60 years or older and causes significant pain and disability. Walking is considered a "gold standard" treatment option for reducing knee osteoarthritis pain and maintaining joint mobility but does not reduce pain for all adults with knee osteoarthritis pain and may induce pain-particularly when starting a walking routine. The mechanism by which walking is helpful for knee osteoarthritis pain is unclear. Quantitative sensory testing has revealed that knee osteoarthritis pain has both peripheral and central components, which vary by individual.

Objective

The purpose of this study was to better understand the mechanisms underlying the value of walking for knee pain.

Methods

We conducted a pretest/posttest s

SUBMITTER: Klinedinst NJ 

PROVIDER: S-EPMC9246935 | biostudies-literature | 2022 Jul-Aug 01

REPOSITORIES: biostudies-literature