Burn Injury-Induced Extracellular Vesicle Production and Characteristics.

ABSTRACT:

Abstract

Extracellular vesicles (EVs) are nano-sized membrane-bound particles containing biologically active cargo molecules. The production and molecular composition of EVs reflect the physiological state of parent cells, and once released into the circulation, they exert pleiotropic functions via transferring cargo contents. Thus, circulating EVs not only serve as biomarkers, but also mediators in disease processes or injury responses. In the present study, we performed a comprehensive analysis of plasma EVs from burn patients and healthy subjects, characterizing their size distribution, concentration, temporal changes, cell origins, and cargo protein contents. Our results indicated that burn injury induced a significant increase in circulating EVs, the response peaked at the tim

SUBMITTER: Yang X 

PROVIDER: S-EPMC9246995 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature