Deciphering associations between three RNA splicing-related genetic variants and lung cancer risk.

ABSTRACT: Limited efforts have been made in assessing the effect of genome-wide profiling of RNA splicing-related variation on lung cancer risk. In the present study, we first identified RNA splicing-related genetic variants linked to lung cancer in a genome-wide profiling analysis and then conducted a two-stage (discovery and replication) association study in populations of European ancestry. Discovery and validation were conducted sequentially with a total of 29,266 cases and 56,450 controls from both the Transdisciplinary Research in Cancer of the Lung and the International Lung Cancer Consortium as well as the OncoArray database. For those variants identified as significant in the two datasets, we further performed stratified analyses by smoking status and histological type and investigated thei

SUBMITTER: Yang W 

PROVIDER: S-EPMC9247007 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature