Impact of adolescent intermittent ethanol exposure in male and female rats on social drinking and neuropeptide gene expression.

ABSTRACT:

Background

Alcohol use during adolescence can alter maturational changes that occur in brain regions associated with social and emotional responding. Our previous studies have shown that adult male, but not female rats demonstrate social anxiety-like alterations and enhanced sensitivity to ethanol-induced social facilitation following adolescent intermittent ethanol exposure (AIE). These consequences of AIE may influence adult social drinking in a sex-specific manner.

Methods

To test the effects of AIE on social drinking, male and female Sprague-Dawley rats exposed to water or ethanol (0 or 4 g/kg, intragastrically, every other day, between postnatal day [P] 25 and 45) were tested as adults (P72-83) in a social drinking paradigm (30-minute access to a 10% ethanol solution in

SUBMITTER: Towner TT 

PROVIDER: S-EPMC9247011 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature