T₂ -oximetry-based cerebral venous oxygenation mapping using Fourier-transform-based velocity-selective pulse trains.

ABSTRACT:

Purpose

To develop a T₂ -oximetry method for quantitative mapping of cerebral venous oxygenation fraction (Y_v ) using Fourier-transform-based velocity-selective (FT-VS) pulse trains.

Methods

The venous isolation preparation was achieved by using an FT-VS inversion plus a nonselective inversion (NSI) pulse to null the arterial blood signal while minimally affected capillary blood flows out into the venular vasculature during the outflow time (TO), and then applying an Fourier transform based velocity selective saturation (FT-VSS) pulse to suppress the tissue signal. A multi-echo readout was employed to obtain venous T₂ (T_2,v ) efficiently with the last echo used to detect the residual CSF signal and correct its contamination in the

SUBMITTER: Li W 

PROVIDER: S-EPMC9247032 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature