Changes in interferon-γ release assay readout after COVID-19 vaccination: A prospective cohort study.

ABSTRACT:

Objectives

Interferon-γ release assays (IGRAs) are widely used in public health practice to diagnose latent tuberculosis. During the COVID-19 pandemic and rollout of COVID-19 vaccination, it has remained unclear whether COVID-19 vaccines interfere with IGRA readouts.

Methods

We prospectively recruited healthcare workers during their annual occupational health examinations in 2021. Baseline IGRA readouts were compared with follow-up data after the participants had received two doses of COVID-19 vaccination.

Results

A total of 134 baseline IGRA-negative cases (92 with ChAdOx1 vaccine, 27 with mRNA-1273 vaccine, and 15 with heterologous vaccination) and seven baseline IGRA-positive cases were analyzed. Among the baseline IGRA-negative cases, there were decreased interfer

SUBMITTER: Chen NY 

PROVIDER: S-EPMC9247115 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature