Significance and Determinants of Plasma Apelin in Patients With Obstructive Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Recent studies suggest apelin has multiple protective effects in some cardiovascular diseases. However, there are few data concerning apelin levels in patients with obstructive hypertrophic cardiomyopathy (OHCM) or the relationship between apelin levels and severity of OHCM.

Methods

We studied 88 patients with OHCM and 32 control subjects with matched age and sex distribution. Complete medical history was collected and related examinations were performed. Cardiac magnetic resonance (CMR) and echocardiography were employed to characterize cardiac morphology and function. Plasma apelin was measured by enzyme-linked immunosorbent assay (ELISA).

Results

Plasma apelin levels were significantly lower in patients with OHCM than those in control subjects (96.6 ± 34

SUBMITTER: Yang C 

PROVIDER: S-EPMC9247182 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature