Changes in the Transcriptome and Chromatin Landscape in BRAFi-Resistant Melanoma Cells.

ABSTRACT: Metastatic and drug-resistant melanoma are leading causes of skin cancer-associated death. Mitogen-associated protein kinase (MAPK) pathway inhibitors and immunotherapies have provided substantial benefits to patients with melanoma. However, long-term therapeutic efficacy has been limited due to emergence of treatment resistance. Despite the identification of several molecular mechanisms underlying the development of resistant phenotypes, significant progress has still not been made toward the effective treatment of drug-resistant melanoma. Therefore, the identification of new targets and mechanisms driving drug resistance in melanoma represents an unmet medical need. In this study, we performed unbiased RNA-sequencing (RNA-seq) and assay for transposase-accessible chromatin with sequencin

SUBMITTER: Reddi KK 

PROVIDER: S-EPMC9247198 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature