Individualized Functional Subnetworks Connect Human Striatum and Frontal Cortex.

ABSTRACT: The striatum and cerebral cortex are interconnected via multiple recurrent loops that play a major role in many neuropsychiatric conditions. Primate corticostriatal connections can be precisely mapped using invasive tract-tracing. However, noninvasive human research has not mapped these connections with anatomical precision, limited in part by the practice of averaging neuroimaging data across individuals. Here we utilized highly sampled resting-state functional connectivity MRI for individual-specific precision functional mapping (PFM) of corticostriatal connections. We identified ten individual-specific subnetworks linking cortex-predominately frontal cortex-to striatum, most of which converged with nonhuman primate tract-tracing work. These included separable connections between nucleus

SUBMITTER: Gordon EM 

PROVIDER: S-EPMC9247416 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature