Effect of selective serotonin reuptake inhibitor discontinuation on anxiety-like behaviours in mice.

ABSTRACT:

Background

Abrupt cessation of therapy with a selective serotonin reuptake inhibitor (SSRI) is associated with a discontinuation syndrome, typified by numerous disabling symptoms, including anxiety. Surprisingly, little is known of the behavioural effect of SSRI discontinuation in animals.

Aim

Here, the effect of SSRI discontinuation on anxiety-like behaviour was systematically investigated in mice.

Methods

Experiments were based on a three-arm experimental design comprising saline, continued SSRI and discontinued SSRI. Mice were assessed 2 days after SSRI discontinuation over a 5-day period using the elevated plus maze (EPM) and other anxiety tests.

Results

An exploratory experiment found cessation of paroxetine (12 days) was associated with decreased open-arm

SUBMITTER: Collins HM 

PROVIDER: S-EPMC9247435 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature