Increased Levels of Serum IL-15 and TNF-β Indicate the Progression of Human Intracranial Aneurysm.

ABSTRACT:

Objective

Existing evidence suggests that chronic inflammation promotes the progression of human intracranial aneurysm (IA) and many cytokines have been detected to participate in the process of inflammation. However, rare cytokines in plasma have been used as proxies for progression of IA. This study aimed to identify novel cytokines as biomarkers to predict the development of IA.

Methods

Patients with unruptured intracranial aneurysms (UIAs) undergoing microsurgical clipping were prospectively recruited from January 2017 to June 2020 and were separated into two groups based on their ELAPSS score (low risk group < 10, intermediate-high risk group ≥ 10). Propensity score matching (PSM) was used to reduce imbalances in the baseline characteristics between groups. All blood sa

SUBMITTER: Yang S 

PROVIDER: S-EPMC9247574 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature