Anti-oomycete Activity of Chlorhexidine Gluconate: Molecular Docking and in vitro Studies.

ABSTRACT: Saprolegniosis is one of the most catastrophic oomycete diseases of freshwater fish caused by the members of the genus Saprolegnia. The disease is responsible for huge economic losses in the aquaculture industry worldwide. Until 2002, Saprolegnia infections were effectively controlled by using malachite green. However, the drug has been banned for use in aquaculture due to its harmful effect. Therefore, it has become important to find an alternate and safe anti-oomycete agent that is effective against Saprolegnia. In this study, we investigated the anti-oomycete activity of chlorhexidine gluconate (CHG) against Saprolegnia. Before in vitro evaluation, molecular docking was carried out to explore the binding of CHG with vital proteins of Saprolegnia

SUBMITTER: Thakuria D 

PROVIDER: S-EPMC9247576 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature