Bubblewrap: Online tiling and real-time flow prediction on neural manifolds.

ABSTRACT: While most classic studies of function in experimental neuroscience have focused on the coding properties of individual neurons, recent developments in recording technologies have resulted in an increasing emphasis on the dynamics of neural populations. This has given rise to a wide variety of models for analyzing population activity in relation to experimental variables, but direct testing of many neural population hypotheses requires intervening in the system based on current neural state, necessitating models capable of inferring neural state online. Existing approaches, primarily based on dynamical systems, require strong parametric assumptions that are easily violated in the noise-dominated regime and do not scale well to the thousands of data channels in modern experiments. To addres

SUBMITTER: Draelos A 

PROVIDER: S-EPMC9247712 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature