Association of Molecular Senescence Markers in Late-Life Depression With Clinical Characteristics and Treatment Outcome.

ABSTRACT:

Importance

Many older adults with depression do not experience remission with antidepressant treatment, and markers of cellular senescence in late-life depression (LLD) are associated with greater severity of depression, greater executive dysfunction, and higher medical illness burden. Since these clinical characteristics are associated with remission in LLD, molecular and cellular senescence abnormalities could be a possible biological mechanism underlying poor treatment response in this population.

Objective

To examine whether the senescence-associated secretory phenotype (SASP) index was associated with the likelihood of remission from a depressive episode in older adults.

Design, setting, and participants

A nonrandomized, open-label clinical trial was conducted be

SUBMITTER: Diniz BS 

PROVIDER: S-EPMC9247739 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature