Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes.

ABSTRACT: Preeclampsia is a multi-organ complication of pregnancy characterized by sudden hypertension and proteinuria that is among the leading causes of preterm delivery and maternal morbidity and mortality worldwide. The heterogeneity of preeclampsia poses a challenge for understanding its etiology and molecular basis. Intriguingly, risk for the condition increases in high-altitude regions such as the Peruvian Andes. To investigate the genetic basis of preeclampsia in a population living at high altitude, we characterized genome-wide variation in a cohort of preeclamptic and healthy Andean families (n = 883) from Puno, Peru, a city located above 3,800 meters of altitude. Our study collected genomic DNA and medical records from case-control trios and duos in local hospital settings. We generated g

SUBMITTER: Nieves-Colon MA 

PROVIDER: S-EPMC9247825 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature