Alcohol use disorder, psychiatric comorbidities, marriage and divorce in a high-risk sample.

ABSTRACT:

Objective

To examine associations between alcohol use disorder (AUD), its psychiatric comorbidities, and their interactions, with marital outcomes in a diverse high-risk, genetically informative sample.

Method

Participants included European ancestry (EA; n = 4,045) and African ancestry (AA; n = 1,550) individuals from the multigenerational Collaborative Study on the Genetics of Alcoholism (COGA) sample (56% female, M_age ∼ 41 years). Outcomes were lifetime marriage and divorce. Predictors included lifetime AUD, an alcohol problems polygenic score (PRS), and AUD comorbidities, including conduct or antisocial personality disorder (ASP), cannabis dependence/abuse (CAN), frequent tobacco use (TOB), and major depressive disorder (MDD). Mixed effect

SUBMITTER: Thomas NS 

PROVIDER: S-EPMC9247836 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature