The Contribution of PDCD6 Polymorphisms to Oral Cancer Risk.

ABSTRACT:

Background/aim

Programmed cell death 6 (PDCD6) is up-regulated and highly expressed in early apoptotic cells. In several types of cancer, such as cervical, breast and lung cancers, the association of PDCD6 genotypes have been investigated. However, the contribution of PDCD6 variant genotypes to oral cancer has never been examined. The current study aimed to evaluate the contribution of the PDCD6 rs4957014 and rs3756712 genotypes to the risk of oral cancer in Taiwan.

Patients and methods

The contribution of PDCD6 genotypes to oral cancer risk was examined among 958 patients with lung cancer and 958 age- and sex-matched healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR- RFLP).

Results

The data showed that the hetero-variant GT a

SUBMITTER: Shih LC 

PROVIDER: S-EPMC9247878 | biostudies-literature | 2022 Jul-Aug

REPOSITORIES: biostudies-literature