HIV drug resistance in a community-randomized trial of universal testing and treatment: HPTN 071 (PopART).

ABSTRACT:

Introduction

Universal HIV testing and treatment (UTT) has individual and public health benefits. HPTN 071 (PopART), a community-randomized trial in Zambia and South Africa, demonstrated that UTT decreased HIV incidence. This endpoint was assessed in a cohort of >48,000 randomly selected adults in the study communities. We evaluated the impact of UTT on HIV drug resistance in this cohort and compared other resistance-related outcomes in participants with recent versus non-recent HIV infection.

Methods

Two years after the start of HPTN 071 (2016-2017), 6259 participants were HIV positive and 1902 were viremic (viral load >400 copies/ml). HIV genotyping and antiretroviral (ARV) drug testing were performed for viremic participants in three groups: seroconverters (infected <1 ye

SUBMITTER: Fogel JM 

PROVIDER: S-EPMC9248006 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature