Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity.

ABSTRACT:

Background

Second-hand smoke (SHS) exposure is associated with paediatric asthma, and oxidative stress is believed to play a role in mediating this association. The nuclear factor (erythroid-derived 2)-like 2 (NFE2L2) is important for the defence against oxidative stress.

Objective

To explore interactions between NFE2L2 genotype and SHS exposure in paediatric asthma risk.

Methods

We used a genotyped subset of patients of European ancestry (N = 669, median age at enrolment = 6.8 years) enrolled in the clinical cohort Greater Cincinnati Pediatric Clinic Repository as the study population, and a population-based paediatric cohort (N = 791) to replicate our findings. History of asthma diagnosis was obtained from medical records, and SHS exposure was obtained from question

SUBMITTER: Johansson E 

PROVIDER: S-EPMC9248014 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature