A population-based validation study of the 8th edition UICC/AJCC TNM staging system for cutaneous melanoma.

ABSTRACT:

Background

The 8^th edition UICC/AJCC TNM8 (Tumour, Nodes, Metastasis) melanoma staging system introduced several modifications from the 7^th edition (TNM7), resulting in changes in survival and subgroup composition. We set out to address the limited validation of TNM8 (stages I-IV) in large population-based datasets.

Methods

This retrospective cohort-study included 6,414 patients from the population-based Ontario Cancer Registry diagnosed with cutaneous melanoma between January 1, 2007 and December 31, 2012. Kaplan-Meier curves estimated the melanoma-specific survival (MSS) and overall survival (OS). Cox proportional hazard models were used to estimate adjusted hazard ratios for MSS and OS across stage groups. The Schemper-Henderson measure was used to a

SUBMITTER: Hynes MC 

PROVIDER: S-EPMC9248086 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature