Placenta-derived proteins across gestation in healthy pregnancies-a novel approach to assess placental function?

ABSTRACT:

Background

Placenta-derived proteins in the systemic maternal circulation are suggested as potential biomarkers for placental function. However, the identity and longitudinal patterns of such proteins are largely unknown due to the inaccessibility of the human placenta and limitations in assay technologies. We aimed to identify proteins derived from and taken up by the placenta in the maternal circulation. Furthermore, we aimed to describe the longitudinal patterns across gestation of placenta-derived proteins as well as identify placenta-derived proteins that can serve as reference curves for placental function.

Methods

We analyzed proteins in plasma samples collected in two cohorts using the Somalogic 5000-plex platform. Antecubital vein samples were collected at three tim

SUBMITTER: Degnes ML 

PROVIDER: S-EPMC9248112 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature