Associations between proton pump inhibitors and Alzheimer's disease: a nested case-control study using a Korean nationwide health screening cohort.

ABSTRACT:

Background

Safety concerns against the use of proton pump inhibitors (PPIs) based on the risk of dementia, especially Alzheimer's disease (AD), remain controversial. Here, we investigated the likelihood of AD depending on previous PPI exposure, use duration, and PPI generation.

Methods

This nested case-control study comprised 17,225 AD patients who were 1:4 matched with 68,900 controls for age, sex, income, and region of residence from Korean National Health Insurance Service-Health Screening Cohort data between 2002 and 2015 using propensity-score matching method. Conditional and unconditional logistic regression analyses were used to evaluate the effects of previous PPI use on AD adjusting for multiple covariates.

Results

Prior PPI use increased likelihood for AD in

SUBMITTER: Choi HG 

PROVIDER: S-EPMC9248149 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature