Subsequent malaria enhances virus-specific T cell immunity in SIV-infected Chinese rhesus macaques.

ABSTRACT:

Background

Coinfection with HIV and Plasmodium parasites is fairly common, but the sequence of infection with these two pathogens and their impact on disease progression are poorly understood.

Methods

A Chinese rhesus macaque HIV and Plasmodium coinfection model was established to compare the impact of pre-existing and subsequent malaria on the progression of SIV infection.

Results

We found that a pre-existing malaria caused animals to produce a greater number of CD4⁺CCR5⁺ T cells for SIV replication, resulting in higher viral loads. Conversely, subsequent malaria induced a substantially larger proportion of CD4⁺CD28^highCD95^high central memory T cells and a stronger SIV-specific T cell response, maintained the rep

SUBMITTER: Liu G 

PROVIDER: S-EPMC9248186 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature