Mutational landscape of pan-cancer patients with PIK3CA alterations in Chinese population.

ABSTRACT:

Purpose

To analyze the mutational landscape of pan-cancer patients with PIK3CA mutations in Chinese population in real-world.

Methods

We analyzed PIK3CA mutation status in sequencing data of cell-free DNA from plasma and genomic DNA from matched peripheral blood lymphocyte in 11,904 Chinese pan-cancer patients, and compared them with genomic data from the Catalogue of Somatic Mutations in Cancer (COSMIC) database. Besides, concomitant genomic aberrations in PIK3CA-mutated samples were detected to investigate cancer driver genes, as well as their enriched pathways. Meanwhile, the mutations of Alpelisib targeting genes were screened and their co-alterations were analyzed according to OncoKB definition to identify the potential actionable ones.

Results

The proportion of

SUBMITTER: Huang Q 

PROVIDER: S-EPMC9248192 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature