Coexistence of two missense mutations in the KRAS gene in adenocarcinoma of the lung: a possible indicator of poor prognosis.

ABSTRACT:

Background

KRAS mutations are present in up to 30% of patients with lung adenocarcinoma. The two most common KRAS mutations in non-small cell lung cancer (NSCLC) are G12C (~40%) and G12V (~22%). We describe the case of a 63-year-old Asian male patient with a very aggressive lung adenocarcinoma harbouring two coexisting missense mutations in the same exon.

Methods

The patient presented with a 6 cm spiculated lung mass and bilateral mediastinal lymphadenopathy on imaging. A cytology sample was obtained from EBUS-TBNA of mediastinal lymph nodes, and mutation screening was performed by next-generation sequencing using the Ion Torrent Cancer Hotspot panel.

Results

Cytological examination and immunocytochemistry confirmed the presence of metastatic lung adenocarcinoma. The

SUBMITTER: Spinelli M 

PROVIDER: S-EPMC9248237 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature