Influence of supramarginal resection on survival outcomes after gross-total resection of IDH-wild-type glioblastoma.

ABSTRACT:

Objective

The authors' goal was to use a multicenter, observational cohort study to determine whether supramarginal resection (SMR) of FLAIR-hyperintense tumor beyond the contrast-enhanced (CE) area influences the overall survival (OS) of patients with isocitrate dehydrogenase-wild-type (IDH-wt) glioblastoma after gross-total resection (GTR).

Methods

The medical records of 888 patients aged ≥ 18 years who underwent resection of GBM between January 2011 and December 2017 were reviewed. Volumetric measurements of the CE tumor and surrounding FLAIR-hyperintense tumor were performed, clinical variables were obtained, and associations with OS were analyzed.

Results

In total, 101 patients with newly diagnosed IDH-wt GBM who underwent GTR of the CE tumor met the inclusion cr

SUBMITTER: Vivas-Buitrago T 

PROVIDER: S-EPMC9248270 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature