Differential DNA Methylation and Cardiometabolic Risk in African American Mother-Adolescent Dyads.

ABSTRACT:

Background

Cardiovascular disease disproportionately affects African Americans as the leading cause of morbidity and mortality. Among African Americans, compared to other racial groups, cardiovascular disease onset occurs at an earlier age due to a higher prevalence of cardiometabolic risk factors, particularly obesity, hypertension and type 2 diabetes. Emerging evidence suggests that heritable epigenetic processes are related to increased cardiovascular disease risk, but this is largely unexplored in adolescents or across generations.

Materials and methods

In a cross-sectional descriptive pilot study in low-income African American mother-adolescent dyads, we examined associations between DNA methylation and the cardiometabolic indicators of body mass index, waist circumfere

SUBMITTER: Gentry AE 

PROVIDER: S-EPMC9248288 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature