Real-World Effects of Antibiotic Treatment on Acute COPD Exacerbations in Outpatients: A Cohort Study under the PharmLines Initiative.

ABSTRACT:

Background

Although antibiotic treatment is recommended for acute exacerbations of chronic obstructive pulmonary disease (AECOPD), its value in real-world settings is still controversial.

Objectives

This study aimed to evaluate the short- and long-term effects of antibiotic treatment on AECOPD outpatients.

Methods

A cohort study was conducted under the PharmLines Initiative. We included participants with a first recorded diagnosis of COPD who received systemic glucocorticoid treatment for an AECOPD episode. The exposed and reference groups were defined based on any antibiotic prescription during the AECOPD treatment. The short-term outcome was AECOPD treatment failure within 14-30 days after the index date. The long-term outcome was time to the next exacerbation. Adju

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9248298 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature