Association between stressful life events and grey matter volume in the medial prefrontal cortex: A 2-year longitudinal study.

ABSTRACT: Stressful life events (SLEs) in adulthood are a risk factor for various disorders such as depression, cancer or infections. Part of this risk is mediated through pathways altering brain physiology and structure. There is a lack of longitudinal studies examining associations between SLEs and brain structural changes. High-resolution structural magnetic resonance imaging data of 212 healthy subjects were acquired at baseline and after 2 years. Voxel-based morphometry was used to identify associations between SLEs using the Life Events Questionnaire and grey matter volume (GMV) changes during the 2-year period in an ROI approach. Furthermore, we assessed adverse childhood experiences as a possible moderator of SLEs-GMV change associations. SLEs were negatively associated with GMV changes in t

SUBMITTER: Ringwald KG 

PROVIDER: S-EPMC9248310 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature