Tumor-expressed microRNAs associated with venous thromboembolism in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer patients have an increased risk of developing venous thromboembolism (VTE), resulting in increased morbidity and mortality. Because the exact mechanism is yet unknown, risk prediction is still challenging; therefore, new biomarkers are needed. MicroRNAs (miRNAs) are small, relatively stable RNAs, that regulate a variety of cellular processes, and are easily measured in body fluids.

Objective

The aim of this study was to identify novel tumor-expressed miRNAs associated with VTE.

Methods

In a cohort of 418 colorectal cancer patients diagnosed between 2001 and 2015 at the Leiden University Medical Center, 23 patients (5.5%) developed VTE 1 year before or after cancer diagnosis. Based on availability of frozen tumor material, tumor cells of 17

SUBMITTER: Anijs RJS 

PROVIDER: S-EPMC9248312 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature