Defining Biological Phenotypes of Mild Traumatic Brain Injury Using Saliva MicroRNA Profiles.

ABSTRACT: Concussion is a heterogeneous injury that relies predominantly on subjective symptom reports for patient assessment and treatment. Developing an objective, biological test could aid phenotypic categorization of concussion patients, leading to advances in personalized treatment. This prospective multi-center study employed saliva micro-ribonucleic acid (miRNA) levels to stratify 251 individuals with concussion into biological subgroups. Using miRNA biological clusters, our objective was to assess for differences in medical/demographic characteristics, symptoms, and functional measures of balance and cognition. The miRNAs that best defined each cluster were used to identify physiological pathways that characterized each cluster. The 251 participants (mean age: 18 ± 7 years; 57% male) were op

SUBMITTER: Hicks SD 

PROVIDER: S-EPMC9248343 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature