Ni-electrocatalytic Csp³-Csp³ doubly decarboxylative coupling.

ABSTRACT: Cross-coupling between two similar or identical functional groups to form a new C-C bond is a powerful tool to rapidly assemble complex molecules from readily available building units, as seen with olefin cross-metathesis or various types of cross-electrophile coupling^1,2. The Kolbe electrolysis involves the oxidative electrochemical decarboxylation of alkyl carboxylic acids to their corresponding radical species followed by recombination to generate a new C-C bond^3-12. As one of the oldest known Csp³-Csp³ bond-forming reactions, it holds incredible promise for organic synthesis, yet its use has been almost non-existent. From the perspective of synthesis design, this transformation could allow one to agnostically execute syntheses without regard

SUBMITTER: Zhang B 

PROVIDER: S-EPMC9248350 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature