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The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D₃ Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer.

ABSTRACT: Active vitamin D₃, 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], and its synthetically derived analogs possess potent anticancer properties. In breast cancer (BC) cells, 1,25(OH)₂D₃ blocks cell proliferation and induces apoptosis through different cell-type specific mechanisms. In this study, we evaluated if the combination of the potent vitamin D₃ analog, inecalcitol, with a selective CDK4/6 inhibitor, palbociclib, enhanced the antiproliferative effects of both single compounds in hormone-sensitive (ER⁺) BC, for which palbociclib treatment is already approved, but also in triple-negative BC (TNBC). Inecalcitol and palbociclib combination treatment decreased cell proliferation in both ER⁺ (T47D-MCF

SUBMITTER: Vanhevel J

PROVIDER: S-EPMC9248359 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Dataset Information

The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D₃ Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer.

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Dataset Information

The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D3 Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The Combination of the CDK4/6 Inhibitor, Palbociclib, With the Vitamin D₃ Analog, Inecalcitol, Has Potent In Vitro and In Vivo Anticancer Effects in Hormone-Sensitive Breast Cancer, But Has a More Limited Effect in Triple-Negative Breast Cancer.