Clinical reliability of genomic data obtained from spinal metastatic tumor samples.

ABSTRACT:

Background

The role of tumor genomic profiling is rapidly growing as it results in targeted, personalized, cancer therapy. Though routinely used in clinical practice, there are no data exploring the reliability of genomic data obtained from spine metastases samples often leading to multiple biopsies in clinical practice. This study compares the genomic tumor landscape between spinal metastases and the corresponding primary tumors as well as between spinal metastases and visceral metastases.

Methods

Spine tumor samples, obtained for routine clinical care from 2013 to 2019, were analyzed using MSK-IMPACT, a next-generation sequencing assay. These samples were matched to primary or metastatic tumors from the corresponding patients. A concordance rate for genomic alterations was

SUBMITTER: Barzilai O 

PROVIDER: S-EPMC9248391 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature