Detection of tumor-specific DNA methylation markers in the blood of patients with pituitary neuroendocrine tumors.

ABSTRACT:

Background

DNA methylation abnormalities are pervasive in pituitary neuroendocrine tumors (PitNETs). The feasibility to detect methylome alterations in circulating cell-free DNA (cfDNA) has been reported for several central nervous system (CNS) tumors but not across PitNETs. The aim of the study was to use the liquid biopsy (LB) approach to detect PitNET-specific methylation signatures to differentiate these tumors from other sellar diseases.

Methods

We profiled the cfDNA methylome (EPIC array) of 59 serum and 41 plasma LB specimens from patients with PitNETs and other CNS diseases (sellar tumors and other pituitary non-neoplastic diseases, lower-grade gliomas, and skull-base meningiomas) or nontumor conditions, grouped as non-PitNET.

Results

Our results indicated tha

SUBMITTER: Herrgott GA 

PROVIDER: S-EPMC9248407 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature