Understanding the Potential and Risk of Bacterial Siderophores in Cancer.

ABSTRACT: Siderophores are iron chelating molecules produced by nearly all organisms, most notably by bacteria, to efficiently sequester the limited iron that is available in the environment. Siderophores are an essential component of mammalian iron homeostasis and the ongoing interspecies competition for iron. Bacteria produce a broad repertoire of siderophores with a canonical role in iron chelation and the capacity to perform versatile functions such as interacting with other microbes and the host immune system. Siderophores are a vast area of untapped potential in the field of cancer research because cancer cells demand increased iron concentrations to sustain rapid proliferation. Studies investigating siderophores as therapeutics in cancer generally focused on the role of a few siderophores as

SUBMITTER: Pita-Grisanti V 

PROVIDER: S-EPMC9248441 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature